![]() ![]() The most common clinical manifestations of CanL due to L. Consequently, CanL is characterized by a wide variety of non-specific clinical presentations ranging from asymptomatic infection to a severe fatal clinical disease, mainly depending on the host’s Th1/Th2 immune responsiveness. Dogs are the main peridomestic reservoir host of the protozoa, developing a chronic and multisystemic infection that may potentially involve any organ. This zoonotic sand fly-borne disease is one of the world’s most important neglected illnesses, though it is potentially fatal to humans if left untreated. ![]() Leishmania infantum (Kinetoplastida, Trypanosomatidae) has been recognised as the main causative agent of canine leishmaniasis (CanL). The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ![]() If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. ![]()
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